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False negatives in task-fMRI studies with typical sample sizes

An article on biorxiv.org (Lohmann G et al., Inflated False Negative Rates Undermine Reproducibility in Task-Based fMRI) investigates false negative rates in task-fMRI studies (specifically in this paper, motor and emotion tasks from the Human Connectome Project) with various sample sizes. Many task-fMRI studies employ subjects of about 20-40, a range where the authors argue that false negatives can be a significant problem. This brings up an interesting counterpoint (although not a counter-argument) to the widely discussed Eklund paper.

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