Functional Imaging Paradigms
This “Functional Imaging Paradigm” section contains brief fMRI paradigm descriptions that were requested from presenters in the fMRI portion of this meeting. The authors have all had experience and success using these specific paradigms for presurgical mapping and other clinical scenarios. Not all ASFNR speakers submitted a paradigm or all of the paradigms used at their respective institutions. There are undoubtedly successful paradigms at other institutions not represented here. Also, specific paradigm timing parameters are influenced by field strength, coil design, delivery systems, other environmental factors, and post-processing strategies. Consequently, differences in paradigm parameters described here are less pertinent to the educational effort than the overall paradigm designs. The section contains a variety of paradigms for mapping motor, premotor, speech and language, vision, and memory functions that are intended to promote the translation of clinical presurgical mapping services among the institutions of meeting attendees. However, the standardization of presurgical mapping paradigms is an evolving process, and the contents herein do not represent an official recommendation or endorsement by the ASFNR. Full paradigm document available for members on the members homepage. A BOLD fMRI workshop is offered each year in conjunction with the Annual Meeting.
Paradigm Parameters and Slides
Sentence Completion
Sentence Completion Task Parameters*
Gradient Echo EPI sequence
Field Strength: 3T
TR: 2000
TE: 30
Matrix: 64×64
FOV: 24 cm
Slice Thickness: 4 mm
Parallel Factor: 2
Scan Length: 4 min
*from Faro et al multi-center trial.
Download this Paradigm in a PowerPoint File (Member Access)
Silent Word Generation
Gradient Echo EPI sequence
Field Strength: 3T
TR: 2000
TE: 30
Matrix: 64×64
FOV: 24 cm
Slice Thickness: 4 mm
Parallel Factor: 2
Scan Length: 4 min
6 cycles = 4 min.
*from Faro et al multi-center trial.
Rhyming
Rhyming Task Parameters:
Gradient Echo EPI sequence
Field Strength: 3T
TR: 2000
TE: 30
Matrix: 64×64
FOV: 24 cm
Slice Thickness: 4 mm
Parallel Factor: 2
Scan Length: 4 min
Antonym Generation
Gradient Echo EPI sequence
Field Strength: 3T
TR: 2000
TE: 30
Matrix: 64×64
FOV: 24 cm
Slice Thickness: 4 mm
Parallel Factor: 2
Scan Length: 2 min 40 sec
Passive Story Listening
Gradient Echo EPI sequence
Field Strength: 3T
TR: 2000
TE: 30
Matrix: 64×64
FOV: 24 cm
Slice Thickness: 4 mm
Parallel Factor: 2
Scan Length: 4 min
Stimuli: The patient listens to 20 seconds of a story (selected passages from The Tale of Peter Rabbit, by Beatrix Potter).
Control: The patient listens to 20 seconds of the same story played backwards.
(Reading performed by Ann Marie Rydberg)
Object Naming
Gradient Echo EPI sequence
Field Strength: 3T
TR: 2000
TE: 30
Matrix: 64×64
FOV: 24 cm
Slice Thickness: 4 mm
Parallel Factor: 2
Scan Length: 4 min
Citation: Brodeur MB, Dionne-Dostie E, Montreuil T, Lepage M (2010) The Bank of Standardized Stimuli (BOSS), a New Set of 480 Normative Photos of Objects to Be Used as Visual Stimuli in Cognitive Research. PLoS ONE 5(5): e10773. https://doi.org/10.1371/journal.pone.0010773